diff --git a/src/thread.c b/src/thread.c
index c03cdda0fae..1ded8f55f50 100644
--- a/src/thread.c
+++ b/src/thread.c
@@ -97,7 +97,12 @@ post_acquire_global_lock (struct thread_state *self)
 static void
 acquire_global_lock (struct thread_state *self)
 {
-  sys_mutex_lock (&global_lock);
+  /* If some Lisp was interrupted by C-g while inside pselect, the
+     signal handler could have called maybe_reacquire_global_lock, in
+     which case we are already holding the lock and shouldn't try
+     taking it again, or else we will hang forever.  */
+  if (!(self && self->not_holding_lock))
+    sys_mutex_lock (&global_lock);
   post_acquire_global_lock (self);
 }