diff --git a/lisp/progmodes/cperl-mode.el b/lisp/progmodes/cperl-mode.el
index a23505a9d3b..fe9612a09a9 100644
--- a/lisp/progmodes/cperl-mode.el
+++ b/lisp/progmodes/cperl-mode.el
@@ -1019,15 +1019,9 @@ Unless KEEP, removes the old indentation."
       (define-key map [(control ?c) (control ?h) ?v]
 	;;(concat (char-to-string help-char) "v") ; does not work
 	'cperl-get-help))
-    (substitute-key-definition
-     'indent-sexp 'cperl-indent-exp
-     map global-map)
-    (substitute-key-definition
-     'indent-region 'cperl-indent-region
-     map global-map)
-    (substitute-key-definition
-     'indent-for-comment 'cperl-indent-for-comment
-     map global-map)
+    (define-key map [remap indent-sexp]        #'cperl-indent-exp)
+    (define-key map [remap indent-region]      #'cperl-indent-region)
+    (define-key map [remap indent-for-comment] #'cperl-indent-for-comment)
     map)
   "Keymap used in CPerl mode.")