diff --git a/lisp/progmodes/python.el b/lisp/progmodes/python.el
index a42e2b2a28a..2dc0441bd47 100644
--- a/lisp/progmodes/python.el
+++ b/lisp/progmodes/python.el
@@ -4537,6 +4537,13 @@ def __PYTHON_EL_native_completion_setup():
             if not is_ipython:
                 readline.set_completer(new_completer)
             else:
+                # Ensure that rlcompleter.__main__ and __main__ are identical.
+                # (Bug#76205)
+                import sys
+                try:
+                    sys.modules['rlcompleter'].__main__ = sys.modules['__main__']
+                except KeyError:
+                    pass
                 # Try both initializations to cope with all IPython versions.
                 # This works fine for IPython 3.x but not for earlier:
                 readline.set_completer(new_completer)